A groundbreaking Trojan horse strategy using cesium nanosalts has emerged as a potent anti-cancer therapy, as demonstrated by a team led by renowned researchers at the Changchun Institute of Applied Chemistry. This innovative approach involves the construction of biodegradable cesium nanosalts, which possess the remarkable ability to activate anti-tumor immunity through pyroptosis and metabolic intervention. The nanosalts employ a clever Trojan horse strategy, inducing ion endocytosis in tumor cells, disrupting their ion balance, and triggering a surge in osmotic pressure, ultimately leading to pyroptosis. Cesium ions (Cs+) play a pivotal role by inhibiting the ion channel activity of sodium/glucose cotransporters, thereby impeding glucose transport. The addition of docosahexaenoic acid (DHA) not only amplifies pyroptosis but also initiates immunogenic ferroptosis, further enhancing the anti-tumor effects. These nanosalts release damage-related molecular patterns, triggering a robust anti-tumor immune response. The research, published in CCS Chemistry, showcases the potential of nanosalts as a novel and effective approach to treating malignant tumors.
